[Myasthenia gravis associated with nivolumab]. / Miastenia grave asociada a nivolumab.

TITLE: Miastenia grave asociada a nivolumab.

Anemia hemolítica autoinmune fatal en un paciente con linfoma marginal esplénico con linfocitos vellosos

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Eritroféresis de donante único: estudio de 50 procedimientos y evaluación de su eficacia leucorreductora / Erythropheresis of the single donor: study of 50 procedures and evaluation of their efficacy in reducing leucocytes

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[Ki-1+ large-cell anaplastic lymphoma with a leukemic appearance. Study of a case]. / Linfoma anaplásico de célula grande Ki-1 (+) con expresión leucémica. Estudio de un caso.

Ki-1 anaplastic large cell lymphoma is a well-described subtype of non-Hodgkin's lymphoma with distinctive characteristics from the cytological, immunohistochemical and clinical points of view. One of the clinical behavior characteristic is that it rarely evolves into a leukaemic phase. We report the case of a 72-year-old man in which the appearance of tumor cells in peripheral blood was one of the most revealing information. The patient showed B-symptoms, bicytopenia and bone marrow involvement, together with hepatosplenomegaly and right axilar adenopathy, which after biopsied lead to Ki-1 anaplastic large cell lymphoma's diagnosis (stage IV-B). As far as the treatment and evolution are concerned, we choose a polychemotherapy (ACOP-B) because of the patient's age. Up to now clinical and analitical course is excellent and the patient is now in remission.